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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD1A
All Species:
5.45
Human Site:
S528
Identified Species:
9.23
UniProt:
O15047
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O15047
NP_055527.1
1707
186034
S528
L
G
A
R
D
T
G
S
E
V
P
S
G
S
G
Chimpanzee
Pan troglodytes
XP_523492
1707
185692
S528
L
G
A
R
D
T
G
S
E
V
P
S
G
S
G
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_848999
1330
145541
S267
F
G
Q
F
T
P
Q
S
S
Q
G
T
P
Y
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFT2
1985
215333
E575
L
P
D
S
D
E
D
E
D
L
G
L
G
L
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506028
1287
141359
I224
V
D
G
V
L
L
V
I
V
K
E
L
K
A
I
Chicken
Gallus gallus
Q5F3P8
2008
223067
N585
I
P
G
T
A
S
L
N
Q
N
S
R
G
T
S
Frog
Xenopus laevis
Q66J90
1938
216239
I550
S
S
T
G
L
E
D
I
S
P
T
P
L
P
D
Zebra Danio
Brachydanio rerio
Q1LY77
1844
204122
A570
R
G
T
A
S
L
L
A
N
S
R
G
M
S
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001015221
1641
188364
I528
L
D
T
R
I
A
L
I
F
K
G
K
T
F
G
Honey Bee
Apis mellifera
XP_395451
1406
159180
A343
L
D
L
D
T
R
I
A
M
L
L
K
D
K
A
Nematode Worm
Caenorhab. elegans
Q18221
1507
171664
A444
V
H
I
K
E
R
T
A
V
I
R
G
K
N
Q
Sea Urchin
Strong. purpuratus
XP_791552
1963
220543
D606
D
S
R
T
Y
R
D
D
H
R
D
K
K
K
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P38827
1080
123894
Q17
A
S
S
G
S
Y
R
Q
P
Q
E
Q
P
Q
Y
Red Bread Mold
Neurospora crassa
Q8X0S9
1313
145607
P250
D
D
A
P
P
S
D
P
R
L
A
H
G
G
K
Conservation
Percent
Protein Identity:
100
99.5
N.A.
73.2
N.A.
37
N.A.
N.A.
27.7
34.5
34.1
36.7
N.A.
25.6
24.6
20.9
23.7
Protein Similarity:
100
99.5
N.A.
74.7
N.A.
49.5
N.A.
N.A.
38.7
47.5
48.6
50.7
N.A.
41.3
39.6
35.8
39.2
P-Site Identity:
100
100
N.A.
13.3
N.A.
26.6
N.A.
N.A.
0
6.6
0
13.3
N.A.
20
6.6
0
0
P-Site Similarity:
100
100
N.A.
20
N.A.
40
N.A.
N.A.
13.3
40
0
20
N.A.
20
20
40
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
22.2
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
33.8
36.5
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
22
8
8
8
0
22
0
0
8
0
0
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
29
8
8
22
0
29
8
8
0
8
0
8
0
8
% D
% Glu:
0
0
0
0
8
15
0
8
15
0
15
0
0
0
0
% E
% Phe:
8
0
0
8
0
0
0
0
8
0
0
0
0
8
0
% F
% Gly:
0
29
15
15
0
0
15
0
0
0
22
15
36
8
29
% G
% His:
0
8
0
0
0
0
0
0
8
0
0
8
0
0
0
% H
% Ile:
8
0
8
0
8
0
8
22
0
8
0
0
0
0
8
% I
% Lys:
0
0
0
8
0
0
0
0
0
15
0
22
22
15
8
% K
% Leu:
36
0
8
0
15
15
22
0
0
22
8
15
8
8
0
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
8
8
0
0
0
8
0
% N
% Pro:
0
15
0
8
8
8
0
8
8
8
15
8
15
8
8
% P
% Gln:
0
0
8
0
0
0
8
8
8
15
0
8
0
8
8
% Q
% Arg:
8
0
8
22
0
22
8
0
8
8
15
8
0
0
0
% R
% Ser:
8
22
8
8
15
15
0
22
15
8
8
15
0
22
8
% S
% Thr:
0
0
22
15
15
15
8
0
0
0
8
8
8
8
15
% T
% Val:
15
0
0
8
0
0
8
0
15
15
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
8
0
0
0
0
0
0
0
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _